Nykode Therapeutics Reports Final P-II Trial (VB-C-02) Results of VB10.16 + Tecentriq (atezolizumab) for Advanced Cervical Cancer
Shots:
- The P-II trial evaluating VB10.16 + Roche’s Tecentriq in 52 patients with advanced or recurrent, non-resectable HPV16+ cervical cancer at sites in the EU
- The results showed an m-OS of ≥25mos. (not reached) & m-PFS of 6.3mos. in PD-L1+ patients while m-OS for the overall population incl. patients with PD-L1- tumors (16.9mos.), m-PFS (4.1mos.), DoR (17.1mos), ORR & DCR (29% & 75%) in PD-L1+ patients (19% & 60% in the overall population)
- In PD-L1+ patients with one prior line of systemic treatment, ORR & DCR (40% & 80%) with a m-PFS (16.9mos.) & m-OS of ≥25mos. (not reached), was well-tolerated and the safety profile was comparable to checkpoint inhibitor monotx. The company plans to initiate a registrational trial for PD-L1+ patients in the US in Q4’23
Ref: GlobeNewswire | Image: Nykode
Related News:- Nykode Reports Interim Results of VB10.16 in P-II (VB C-02) Trial for the Treatment of Advanced Cervical Cancer
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